Embedded Files
Our research interests fall under the broad scope of organic synthesis and include: total synthesis, structure determination, methods development, structure and reactivity of unstable species, and rearrangement chemistry. We are interested in: the development of key reaction methodology (especially in the areas of radical chemistry), transition metal catalysed processes and catalytic enantioselective synthesis; all aspects of the structure and reactivity of oxonium ions; and the use of biosynthesis and computational methods as predictive tools for the structure determination of complex molecules. All of the above inform and guide our research on complex molecule total synthesis.
Our recent papers
October 4th, 2025
Our recent article devoted to a photoinduced metal-free hydrocarbamoylation of allylamines has been just accepted for publication at the Advanced Synthesis & Catalysis
Keywords: allylamines, γ-amino amides, photoredox catalysis hydrocarbamooyation, Hantzsch esters
Abstract: A photoredox-catalysed protocol for allylamine hydrocarbamoylation under metal-free and mild conditions is reported. The proposed method utilises readily accessible 4-carboxyamido Hantzsch esters as convenient substrates that deliver carbamoyl radicals upon a visible light-mediated SET process. Their addition to various allylamines proceeds with good-to-excellent efficiency and with high levels of regio- and chemoselectivity to provide the corresponding γ-amino acid amides
December 12th, 2024
Our recent article devoted to a photoinduced metal-free hydrocarboxylation of allylamines has been just accepted for publication at the Advanced Synthesis & Catalysis
Keywords: allylamines, γ-amino acids, photoredox, hydrocarboxylation, HAT reagents, thiyl radicals
Abstract: We disclose a new photochemical process to prepare γ-amino acids from allylamines and formic acid salts. The investigated redox-neutral hydrocarboxylation process produces high yields across a wide range of functionalised allylamine substrates with excellent regioselectivity. The developed operationally simple protocol can be readily scaled with low photocatalyst loading (from 1% up to 0.02 mol%) without the need for any precautions to exclude air or moisture. The mechanistic working model utilizes a thiol-catalyzed radical chain process, delivering the hydrogen atom and CO₂ from formic acid salt across the alkene substrate through the carboxylate radical (CO₂•-), a crucial reactive intermediate
March 22nd, 2024
Finally, after few years of the writing, correction and updating our comprehensive review on the Kinugasa reaction has been published in prestigious Organic Reactions by Wiley.
A new promo spot of the Institute of Organic Chemistry PAS
A new promo spot of the Institute of Organic Chemistry PAS
Have you seen already the recent spot of our Institute of Organic Chemistry of the Polish Academy of Sciences in Warsaw, Poland?
If not, carry on!
The Institute of Organic Chemistry of the Polish Academy of Sciences (IOC PAS) is a research unit of category A+ according to the parametrization of the Polish Ministry of Education and Science.
According to the national rankings the IOC PAS is first in the category of scientific institutes conducting research in the field of organic chemistry.
In 2022 in the international ranking of the quality of scientific institutions, SCImago Institutions Rankings (SIR), the IOC PAS took first place in terms of innovation among scientific institutions in Poland and twelfth in the overall SIR ranking.
Marie Skłodowska-Curie in Italy in search of radium
Marie Skłodowska-Curie in Italy in search of radium
“Madame Skłodowska-Curie arrived alone from Paris to Pisa by train on July 30, 1918, at 3:30 a.m.” This is how the extraordinary journey of the two-time Nobel laureate began, during which she travelled with Italian scientists, investigating natural radiation in thermal waters, fumaroles, and rocks. This research tour is probably the least known journey of the Polish Nobel Prize winner, although it lasted three weeks.
We invite you to see our movie that is the result of cooperation among:
• Scientific Centre of the Polish Academy of Sciences in Rome (Agnieszka Stefaniak-Hrycko),
• Institute of Organic Chemistry of the Polish Academy of Sciences in Warsaw (prof. Marcin Górecki),
• Department of Chemistry and Industrial Chemistry of the University of Pisa (prof. Lorenzo Di Bari, prof. Gaetano Angelici, prof. Valentina Domenici)
• Museum of Maria Skłodowska-Curie in Warsaw (Miłka Skalska)
as part of activities to disseminate and promote science.
Dominika's paper devoted to synthesis of amino ketones via cross-coupling and visible light mediated oxidative cleavage was just accepted in Advanced Synthesis & Catalysis
Our new article in Adv. Synth. Catal
Our new article in Adv. Synth. Catal
We report a convenient two-step approach to α-amino ketones involving cross-coupling and oxidative cleavage. The cross-coupling reaction creates a divergent functionalization of the molecular platform, e.g., N-(2-bromoallyl)amine, whereas the oxidative cleavage establishes the carbonyl functionality. This strategy allows for an introduction of aryl/heteroaryl and alkyl groups, either through the Suzuki reaction with arylboronic acids or via dual photoredox/Ni-catalysis to install alkyl groups. The oxidative cleavage to provide target α-amino ketones can be realized either by treating with ozone or by employing milder photochemical protocols involving oxygen or photoexcited nitroarenes as oxidants. We successfully demonstrate the scalability of this protocol, which, together with its simplicity, generality, and its ability to provide access to amino ketones that are inaccessible through other strategies, highlights the suitability of this approach for a wide range of applications across the different chemical sciences.
Google Sites
Report abuse